منابع مشابه
Developmental origin and maintenance of distinct testicular macrophage populations
Testicular macrophages (tMφ) are the principal immune cells of the mammalian testis. Beyond classical immune functions, they have been shown to be important for organogenesis, spermatogenesis, and male hormone production. In the adult testis, two different macrophage populations have been identified based on their distinct tissue localization and morphology, but their developmental origin and m...
متن کاملModulation of testicular macrophage activity by collagenase.
Testicular macrophages (TMs) are located in the interstitial tissue of male gonad. These phagocytic cells take part in forming the organ-specific functional blood-testis barrier and participate in the regulation of the local hormonal balance. In the present study, we isolated TMs from testicular tissues using previously described methods--mechanical (M-TMs) or enzymatic, by treatment with colla...
متن کاملClonal origin of metastatic testicular teratomas.
PURPOSE Testicular teratomas in adult patients are histologically diverse tumors that frequently coexist with other germ cell tumor (GCT) components. These mixed GCTs often metastasize to retroperitoneal lymph nodes where multiple GCT elements are frequently present in the same metastatic lesion. Neither the genetic relationships among the different components in metastatic lesions nor the rela...
متن کاملGerm cell origin of testicular carcinoid tumors.
PURPOSE Carcinoids are neuroendocrine tumors and most frequently occur within tissues derived from the embryonic gut. These tumors can occur in any organ site but are rare in the testis. The cell type giving rise to testicular carcinoid is unknown. We hypothesized that testicular carcinoid may have a germ cell origin. EXPERIMENTAL DESIGN We describe our analysis of protein and genetic markers...
متن کاملEmbryonic origin of the mouse macrophage.
Progenitor cells capable of giving rise to functional macrophages in in vitro culture were first detectable in the fetal yolk sac of the mouse between day 7 and 8 of gestation. Macrophage progenitors were not detectable outside the yolk sac until day 11. Although the early yolk sac contained macrophage precursors, no cells with the morphologic or functional characteristics of mouse promonocytes...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2017
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni.3846